PMID

Data

Article Title

Organization

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.

Biota Scientific Management

Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus.

Kobe Gakuin University

Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.

St. John'S University

Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymeraseß.

Kobe Gakuin University

Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.

Science University of Tokyo

Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.

Kyoto Prefectural University

Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.

Max-Delbr�Ck-Centrum F�R Molekulare Medizin

1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.

Tibotec

GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.

Gilead Sciences

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Pharmasset

Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases beta and lambda from Talaromyces sp.

Tokyo University of Science

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.

Central Pharmaceutical Research Institute

Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.

The University of Texas

Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound.

Microbiotix